AMINO-1MQ

5-Amino-1MQ is a small molecule that blocks the enzyme Nicotinamide N-methyltransferase (NNMT). This enzyme changes the NAD+ salvage pathway by adding a methyl group to nicotinamide, a form of vitamin B3. When NNMT interferes, the enzyme NAMPT cannot turn nicotinamide into NMN, which is needed to create NAD+. Because NAD+ drives cell energy, this shift directly affects how the body uses fuel. Researchers study this compound to better understand metabolism. Studies show it can raise energy use and increase fat breakdown in animals. Scientists also examine how it affects fat cell growth, lipolysis, and age-related changes tied to metabolism. By blocking this pathway, it raises NAD+ levels, supports enzymes like sirtuins, and changes how cells manage energy.