5-Amino-1MQ vs SLU-PP-332
Fat-targeted NNMT block vs ERR-driven exercise mimetic.
| Attribute | 5-Amino-1MQ NNMT inhibitor | SLU-PP-332 ERR agonist exercise mimetic |
|---|---|---|
| Category | Mitochondrial Health & Energy | Mitochondrial Health & Energy |
| Best known for | Metabolic and fat-cell research | ERR agonist exercise-mimetic research |
| In plain English | By inhibiting NNMT, 5-amino-1MQ keeps more NAD+ around and pushes fat cells toward burning rather than storing energy. | It flips on the same gene programs that endurance exercise activates — mitochondrial biogenesis and fat oxidation. |
| How it works | Inhibits NNMT in adipocytes, increasing intracellular NAD+ and SAM and shifting metabolism toward fat oxidation. | Activates ERR transcription factors, upregulating mitochondrial biogenesis, oxidative metabolism, and endurance-related gene expression. |
| Researchers study | Obesity, NAFLD, and muscle stem cell research. | Obesity, endurance performance, and metabolic disease in mouse models. |
| Internet discussion | Discussed as an oral metabolic compound without GLP-1 side effects. | Hyped on longevity and biohacker Twitter as the 'exercise pill.' |
5-Amino-1MQ
Metabolic and fat-cell research
By inhibiting NNMT, 5-amino-1MQ keeps more NAD+ around and pushes fat cells toward burning rather than storing energy.
Inhibits NNMT in adipocytes, increasing intracellular NAD+ and SAM and shifting metabolism toward fat oxidation.
Obesity, NAFLD, and muscle stem cell research.
Discussed as an oral metabolic compound without GLP-1 side effects.
5-Amino-1MQ is an NNMT inhibitor studied for adipocyte metabolism and weight research.
SLU-PP-332
ERR agonist exercise-mimetic research
It flips on the same gene programs that endurance exercise activates — mitochondrial biogenesis and fat oxidation.
Activates ERR transcription factors, upregulating mitochondrial biogenesis, oxidative metabolism, and endurance-related gene expression.
Obesity, endurance performance, and metabolic disease in mouse models.
Hyped on longevity and biohacker Twitter as the 'exercise pill.'
SLU-PP-332 is a small-molecule ERR pan-agonist researched as an exercise mimetic for endurance and metabolism.