SLU-PP-332
- •what is SLU-PP-332
- •SLU-PP-332 ERR agonist
- •exercise mimetic research
- •SLU-PP-332 mitochondrial
- •SLU-PP-332 fat loss
- SLU-PP-332(ERR agonist exercise mimetic)· Mitochondrial Health & Energy
- SLU-PP-332 is an experimental compound that turns on the same cellular switches that endurance exercise turns on — without the exercise. In mouse studies it boosts mitochondrial biogenesis and endurance.
What is it?
SLU-PP-332 is a small-molecule estrogen-related receptor (ERR) pan-agonist developed at Saint Louis University. Although not technically a peptide, it is widely grouped with metabolic research compounds as a leading 'exercise mimetic.'
In plain English
SLU-PP-332 is an experimental compound that turns on the same cellular switches that endurance exercise turns on — without the exercise. In mouse studies it boosts mitochondrial biogenesis and endurance.
How it works
Activates all three ERR isoforms (α, β, γ), driving mitochondrial biogenesis, fat oxidation, and oxidative muscle fiber type shifts that normally require prolonged endurance training.
What researchers study
- •Exercise mimetic research
- •Mitochondrial biogenesis studies
- •Obesity and fat oxidation models
- •Endurance performance research
- •Comparison with AICAR and MOTS-c
What the internet talks about
One of the most-hyped metabolic compounds in longevity, biohacking, and performance forums since its 2023 publication. Common debate: how much animal-research effect will translate to humans.
Bro-science translation
“Endurance exercise in a vial.”
Commonly compared to
Common stack discussions
Discussed alongside MOTS-c, AICAR, NAD+ precursors, and 5-Amino-1MQ in mitochondrial and metabolic stacks.
Related peptides
Related categories
Frequently asked questions
Quick summary
SLU-PP-332 is a small-molecule ERR pan-agonist studied as an exercise mimetic for mitochondrial biogenesis and fat oxidation.

