5-Amino-1MQ

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates NAD+ metabolism and is highly expressed in adipose tissue. It was developed by researchers studying NNMT's role in obesity and metabolic disease. Although technically a small molecule rather than a peptide, it is grouped with research peptides because of its overlapping use in metabolic, fat-loss, and longevity research. It is sold strictly for laboratory research.

Inside your fat cells lives an enzyme called NNMT that, when overactive, contributes to fat storage and disrupts NAD+ metabolism. 5-Amino-1MQ is a research compound that blocks NNMT specifically in fat tissue. In mouse studies, blocking NNMT made obese mice lose fat without changing diet or exercise. It is one of the more talked-about 'metabolic switch' compounds in longevity and biohacker forums.

5-Amino-1MQ selectively inhibits NNMT, an enzyme that consumes SAM and nicotinamide. By blocking NNMT, the compound preserves nicotinamide (a precursor in the NAD+ salvage pathway) and SAM (a methyl donor), while also reducing the production of methylated metabolites that influence adipose tissue gene expression. The net effect in mouse studies is increased adipocyte energy expenditure and reduced fat mass.

• •Obesity and adipose tissue NAD+ metabolism
• •Type 2 diabetes and insulin sensitivity
• •Sarcopenia and muscle stem cell function
• •NNMT enzyme biology
• •Mitochondrial energy expenditure in fat cells

5-Amino-1MQ is a longevity-forum and biohacker favorite, frequently discussed alongside MOTS-c, NAD+ precursors, and SS-31 in mitochondrial-metabolic stacks. Conversations focus on its NNMT mechanism, oral bioavailability (a major advantage over injectable peptides), and mouse data showing fat loss without diet change.

“Flips the fat-cell metabolic switch.”

Most commonly combined with MOTS-c, NAD+ precursors (NMN, NR), SS-31, and other mitochondrial compounds. Forum users sometimes pair it with GLP-1 agonists in metabolic stacks.

5-Amino-1MQ is a small-molecule NNMT inhibitor studied for fat loss, NAD+ preservation, and muscle stem cell function. It is orally bioavailable and is sold strictly for laboratory research.