Semax vs Selank
Focus and cognition vs calm and stress relief.
| Attribute | Semax ACTH(4-10) analog | Selank Tuftsin analog |
|---|---|---|
| Category | Brain & Cognitive Support | Brain & Cognitive Support |
| Best known for | Cognitive enhancement research | Anxiolytic without sedation research |
| In plain English | Semax is the focus peptide. Researchers study how it boosts BDNF and NGF — the brain's growth and repair factors. | Selank is the chill peptide. Researchers study how it provides anti-anxiety effects without the sedation or dependence of benzodiazepines. |
| How it works | Upregulates BDNF and NGF expression, modulates dopamine and serotonin, and inhibits enkephalin breakdown. | Modulates GABA, serotonin, and BDNF; inhibits enkephalinase to increase enkephalin activity. |
| Researchers study | Cognitive function, ischemic stroke recovery, ADHD, and neuroprotection. | Generalized anxiety, stress response, and immune modulation. |
| Internet discussion | Stacked with Selank as the canonical Russian nootropic combo. | The anti-anxiety peptide of choice on nootropic forums. |
Semax
Cognitive enhancement research
Semax is the focus peptide. Researchers study how it boosts BDNF and NGF — the brain's growth and repair factors.
Upregulates BDNF and NGF expression, modulates dopamine and serotonin, and inhibits enkephalin breakdown.
Cognitive function, ischemic stroke recovery, ADHD, and neuroprotection.
Stacked with Selank as the canonical Russian nootropic combo.
Semax is a nootropic peptide researched for BDNF/NGF upregulation and cognitive support.
Selank
Anxiolytic without sedation research
Selank is the chill peptide. Researchers study how it provides anti-anxiety effects without the sedation or dependence of benzodiazepines.
Modulates GABA, serotonin, and BDNF; inhibits enkephalinase to increase enkephalin activity.
Generalized anxiety, stress response, and immune modulation.
The anti-anxiety peptide of choice on nootropic forums.
Selank is an anxiolytic nootropic peptide researched for stress reduction without sedation.