What is a GHRH analog peptide?

A GHRH analog peptide is a synthetic peptide structurally related to growth hormone-releasing hormone, frequently referenced in laboratory investigation of GHRH receptor signaling and pituitary research models.

What does lyophilized mean?

Lyophilized describes a freeze-dried solid form created by sublimating water from a frozen sample under vacuum. Lyophilization improves stability and supports long-term storage of research peptides.

How is Dr. Jays TESA™ supplied?

Dr. Jays TESA™ is supplied as a sealed sterile research vial of lyophilized white-to-off-white peptide powder, with bacteriostatic water included for reconstitution.

What strengths are available?

Dr. Jays TESA™ is available in 5MG and 10MG research vials. Each strength has its own SKU and batch documentation.

What is the recommended storage condition?

Refrigerated storage (approximately 2°C to 8°C) is recommended. Protect the vial from prolonged light exposure and moisture in accordance with general laboratory handling standards.

Is bacteriostatic water included?

Yes. Each Dr. Jays TESA™ order includes bacteriostatic water for accurate reconstitution per documented laboratory procedure.

How is the product packaged for shipment?

Vials are inspected, sealed, labeled, and packed using standard research-product handling procedures before being released to the carrier.

What is laboratory-grade handling?

Laboratory-grade handling refers to working with the compound in a controlled research environment using documented procedures, appropriate personal protective equipment, and consistent record keeping.

What research resources are available?

Dr. Jay's publishes complementary educational reference material through the Knowledge Hub, Peptide Finder™, Peptide University™, the Research Encyclopedia, and the Reconstitution Calculator.

How should research compounds be documented?

Research groups typically record receipt date, batch identifier, storage location, reconstitution preparation, and dispensation events as part of standard laboratory documentation.

What are analytical applications?

Analytical applications include identity, purity, and stability testing using techniques such as HPLC, mass spectrometry, and related instrumentation in a qualified laboratory environment.

Is TESA™ intended for human or animal use?

No. Dr. Jays TESA™ is supplied strictly for laboratory and analytical research applications. It is not intended for human or animal consumption.

Is the vial tamper-evident?

Vials are sealed prior to shipment so that any disturbance to the seal is observable on receipt and inspection.

What if a vial arrives damaged?

Contact customer support with the order reference and photographs of the packaging so a replacement or resolution can be arranged.

How is product quality reviewed?

Vials move through a documented sequence of quality review, packaging verification, batch documentation, storage preparation, and shipment processing.

Where can I find related research compounds?

Use the Peptide Finder™ and the Research Encyclopedia in the Knowledge Hub to navigate related research compound categories.

Is shipping discreet?

Outer packaging does not display product details beyond standard carrier labeling.

What is the typical appearance of the lyophilized powder?

The lyophilized peptide typically appears as a white to off-white solid cake or fine powder inside a clear sterile research vial.

Can the compound be reconstituted?

Reconstitution is performed at the discretion of the qualified laboratory operator using the included bacteriostatic water and documented procedures. Use the Dr. Jay's Reconstitution Calculator for reference math.

Is batch documentation available?

Batch documentation for research-product handling is maintained as part of the documented preparation sequence. Contact support for batch-specific information when needed.

What does 'research grade' mean on this page?

Research grade indicates the product is prepared and supplied for laboratory research and analytical use only — not for clinical, dietary, cosmetic, or consumer applications.

How does TESA™ compare to other GHRH research peptides?

Comparative information across GHRH-family research peptides is published in the Research Encyclopedia and the Peptide University™ educational modules.

Where can I learn more about peptide research fundamentals?

Peptide University™ offers structured educational modules covering peptide chemistry, lyophilization, reconstitution, analytical evaluation, and research documentation.

Tesamorelin is a synthetic stabilized analog of the natural hypothalamic peptide growth-hormone-releasing hormone (GHRH). It retains the complete 44-amino-acid GHRH(1-44) sequence and adds a trans-3-hexenoic acid group at the N-terminus that blocks DPP-4 cleavage and substantially extends the plasma half-life relative to unmodified GHRH. The compound was developed at Theratechnologies and was approved by the U.S. FDA in 2010 under the brand name Egrifta for a specific clinical indication.

How does tesamorelin work?

Tesamorelin is a GHRH receptor agonist. It binds and activates the GHRH receptor (a class B G-protein-coupled receptor expressed prominently on pituitary somatotroph cells) and signals through Gs-coupled adenylyl-cyclase activation and elevation of intracellular cyclic AMP. The downstream signaling cascade in somatotrophs involves protein kinase A activation, phosphorylation of CREB, and stimulation of growth hormone synthesis and secretion. The result is stimulation of pulsatile growth hormone secretion from the pituitary, with downstream effects through the broader growth-hormone axis including hepatic IGF-1 production.

How is tesamorelin different from sermorelin?

Two main differences. First, tesamorelin uses the complete 44-amino-acid GHRH(1-44) scaffold while sermorelin uses the shorter 29-amino-acid GHRH(1-29) scaffold; the longer scaffold in tesamorelin contributes additional receptor-binding-affinity and structural-stability contributions. Second, tesamorelin has the trans-3-hexenoic acid N-terminal modification that blocks DPP-4 cleavage and extends the plasma half-life, while sermorelin does not have an N-terminal stabilization modification and is more rapidly degraded.

How is tesamorelin different from CJC-1295?

Different scaffold, different stability strategy. CJC-1295 (both with-DAC and without-DAC variants) uses the GHRH(1-29) scaffold with amino-acid substitutions that protect against DPP-4 cleavage. The with-DAC variant adds a maleimide-containing linker that produces albumin-binding pharmacokinetics with a multi-day plasma half-life. Tesamorelin uses the full-length GHRH(1-44) scaffold and the trans-3-hexenoic acid N-terminal modification, producing a plasma half-life on the order of 30 minutes — substantially longer than unmodified GHRH but much shorter than the with-DAC variant of CJC-1295.

Is tesamorelin growth hormone?

No. Tesamorelin is GHRH — the upstream hypothalamic releasing hormone that stimulates pituitary growth hormone secretion. It acts on the GHRH receptor on pituitary somatotroph cells to stimulate the cells to synthesize and secrete growth hormone. The growth hormone itself is then released from the pituitary into circulation and produces the downstream effects of the growth-hormone axis. Tesamorelin and growth hormone are different molecules with different sources, different receptors, and different positions in the growth-hormone-axis signaling cascade.

What is DPP-4 and why does it matter for GHRH?

DPP-4 (dipeptidyl peptidase-4) is a serine protease that cleaves N-terminal dipeptides from peptide substrates with specific N-terminal sequences. GHRH has the N-terminal Tyr-Ala dipeptide that is a substrate for DPP-4, and the cleavage produces the N-terminally truncated GHRH(3-44) fragment that is inactive at the GHRH receptor. DPP-4 cleavage is the principal pathway by which natural GHRH is rapidly inactivated in plasma, with a half-life on the order of minutes. The trans-3-hexenoic acid modification on tesamorelin blocks DPP-4 access to the cleavage site and substantially extends the plasma half-life.

What does the trans-3-hexenoic acid modification do?

The trans-3-hexenoic acid group is a small six-carbon acyl chain attached to the N-terminal alpha-amine of the tyrosine at position 1 of tesamorelin. The modification blocks DPP-4 access to the N-terminal Tyr-Ala cleavage site, preventing the rapid DPP-4-mediated inactivation that limits the half-life of unmodified GHRH. The result is a substantial extension of the plasma half-life — from a few minutes for unmodified GHRH to approximately 30 minutes for tesamorelin. The hexenoic-acid modification is a stability modification rather than an albumin-binding lipidation modification.

Who developed tesamorelin?

Tesamorelin was developed at Theratechnologies, a Canadian pharmaceutical company based in Montreal, through its GHRH-analog research program in the 2000s. The compound was approved by the U.S. FDA in 2010 under the brand name Egrifta for a specific clinical indication in adult HIV-infected patients with lipodystrophy. The approval represented the first GHRH analog to reach clinical use as an approved therapeutic for a specific metabolic indication.

Is tesamorelin a GH secretagogue?

Tesamorelin stimulates growth hormone secretion, but it is distinct from the compounds typically referred to as 'GH secretagogues' in the research-peptide literature. The 'GH secretagogue' label is generally used for compounds that act at the GHSR (growth-hormone-secretagogue receptor, also called the ghrelin receptor) — including ipamorelin, hexarelin, GHRP-2, GHRP-6, and others. Tesamorelin acts at the GHRH receptor, not at the GHSR. Both receptor systems can produce growth hormone secretion, but the receptors, signaling cascades, and integrated pharmacology profiles are different.

What is the molecular weight of tesamorelin?

Tesamorelin has a molecular mass of approximately 5196 daltons in the free-base form. The 44-amino-acid GHRH(1-44) backbone contributes the bulk of the mass, with the C-terminal amidation and the trans-3-hexenoic acid N-terminal modification contributing the additional chemistry. The exact mass for a particular batch is reported on the Certificate of Analysis from a reputable research-peptide supplier and confirmed by mass spectrometry.

How is tesamorelin administered in research contexts?

In published research and clinical literature, tesamorelin is administered by subcutaneous injection. The peptide structure is not orally bioavailable in any practical way — like most peptides, the molecule would be degraded in the gastrointestinal tract before significant absorption. The plasma half-life of approximately 30 minutes supports once-daily dosing in research and clinical contexts. The research-peptide supply context contemplates laboratory and analytical work rather than personal administration.

What storage and reconstitution practices apply?

Lyophilized tesamorelin stored sealed at -20 °C or below away from light is generally considered stable for extended periods. The N-terminal hexenoic-acid modification and the full-length scaffold give the compound reasonable chemical stability for a 44-amino-acid peptide. After reconstitution in sterile water or bacteriostatic water, the compound is typically stored refrigerated and used within several weeks. Standard research-laboratory storage and handling practices apply.

How is tesamorelin manufactured?

Research-grade tesamorelin is produced by solid-phase peptide synthesis using Fmoc protecting-group chemistry, with the 44-amino-acid linear sequence assembled on an amide-bond-forming resin (which generates the C-terminal amide on cleavage). The trans-3-hexenoic acid N-terminal modification is performed at the end of the synthesis by reaction of the N-terminal alpha-amine with trans-3-hexenoic acid or an activated derivative. The crude modified peptide is purified by reversed-phase HPLC and characterized by mass spectrometry and other analytical methods.

Is tesamorelin approved as a medicine?

Tesamorelin was approved by the U.S. FDA in 2010 under the brand name Egrifta for a specific clinical indication in adult HIV-infected patients with lipodystrophy. That regulatory approval is the channel through which the compound is used as an approved medicine in the United States. The research-peptide supply of tesamorelin for laboratory work is a separate channel from the approved-product channel; the research-peptide use is intended for laboratory work, not personal administration or clinical use.

What is the half-life of tesamorelin?

The plasma half-life of tesamorelin after subcutaneous administration is approximately 30 minutes. This is substantially longer than the few-minute half-life of unmodified GHRH (due to the DPP-4-cleavage protection from the N-terminal hexenoic-acid modification) but much shorter than the multi-day half-lives of the lipidated long-acting peptides such as semaglutide or cagrilintide. The half-life profile supports once-daily dosing and produces pulsatile growth-hormone-stimulation pharmacology rather than sustained continuous stimulation.

How does tesamorelin compare to growth hormone replacement?

Different mechanism. Growth hormone replacement involves direct administration of growth hormone, which then acts on growth hormone receptors throughout the body. Tesamorelin acts upstream — it stimulates the pituitary somatotrophs to secrete the body's own growth hormone through the GHRH-receptor pathway. The integrated pharmacology of GHRH-receptor stimulation produces pulsatile growth hormone secretion that approximates the natural pulsatile pattern, distinct from the more continuous pattern produced by direct growth hormone administration. The differences are important in research and clinical contexts on the relative effects of pulsatile versus continuous growth-hormone-axis stimulation.

Comprehensive safety characterization of tesamorelin was conducted as part of the regulatory-approval process for the Egrifta product, and the approved-product label includes the documented safety profile for that indication and use context. The research-peptide supply of the compound for laboratory work is a separate channel; the comprehensive safety characterization is applicable to clinical use of the approved product rather than to laboratory research-peptide use. Educational discussion of safety should remain within the laboratory-research and approved-product framings appropriate to the actual use channels rather than extrapolating to off-label or personal-use contexts.

TESA – Research Grade GHRH Analog Peptide lyophilized vial with bacteriostatic water for research

Swiss-SourcedPharmaceutical-GradeLyophilized PowderIn Stock≥99% Purity

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TESA – Research Grade GHRH Analog Peptide

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SKU: FC-TESA-5MG

$45.00

Volume pricing

·5 mg

Sitewide sale price — extra discount by quantity on this line

Quantity	Price / Unit	Discount
5–9	$42.75	5%
10–15	$40.50	10%
16–20	$38.25	15%
21+	$36.00	20%

Strength5 mg

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Research use only — not for human or veterinary consumption.

What you receive

Sealed, lyophilized vial — 5 mg
Bacteriostatic water — appropriate size for reconstitution, included free
Certificate of Analysis available — view COAs

Swiss-sourced · Pharmaceutical-grade · Cold-chain shipped

Research Grade GHRH Analog

Dr. Jays TESA™

A synthetic GHRH analog research peptide supplied lyophilized in sterile sealed research vials. Investigated for GHRH receptor signaling, pituitary function, and IGF-1 pathway research.

5MG · 10MG
Lyophilized
BAC Water Included
Research Grade

View Specifications Explore Research Resources

Dr. Jays TESA™ lyophilized GHRH analog research peptide vial

Research GradeLyophilizedLaboratory UseGHRH Analog

Product Highlights

Engineered for endocrine research workflows

Dr. Jays TESA™ is supplied as a lyophilized, sealed GHRH analog research peptide — prepared around the practical needs of analytical laboratories.

Lyophilized GHRH Analog

Freeze-dried research peptide supplied in a sterile sealed research vial.

5MG & 10MG Vials

Two strengths available for flexible, documented laboratory workflows.

BAC Water Included

Bacteriostatic water included for accurate reconstitution per laboratory standards.

Educational Resources

Backed by Dr. Jay's Knowledge Hub and Peptide University™ reference content.

Product Overview

What is Dr. Jays TESA™?

Dr. Jays TESA™ is a synthetic GHRH analog research peptide, widely referenced in laboratory investigation of growth hormone-releasing hormone receptor signaling, pituitary function, and IGF-1 pathway analytical study.

GHRH analog peptide. Supplied as a lyophilized research peptide in a sealed sterile research vial.
Laboratory investigation. Used in documented analytical workflows in qualified laboratory environments.
Endocrine research models. Reference compound across endocrine, metabolic, and pituitary research models.
Receptor interaction studies. Suited to peptide-receptor binding and signaling investigation.
Scientific research workflows. Supports protocol development, documentation, and reference work.

Research Visualization

GHRH → GH → IGF-1 axis

Illustrative laboratory reference showing the cascade investigated in GHRH analog research models. For educational visualization only.

GHRH Receptor95%

Pituitary GH Output80%

Hepatic IGF-1 Signal65%

Downstream Pathway50%

Laboratory Workflow

From compound to documented review

Stage 1
Research Compound
Stage 2
Laboratory Preparation
Stage 3
Analytical Evaluation
Stage 4
Data Collection
Stage 5
Research Review

Specifications

Product specifications

Product Name	Dr. Jays TESA™
Composition	GHRH Analog Peptide
Format	Lyophilized Powder
Appearance	White to Off-White
Strengths	5MG · 10MG per Vial
Container	Sterile Research Vial
Reconstitution	Bacteriostatic Water Included
Storage	Refrigerated (2–8°C)
Category	Research Peptide
Intended Use	Laboratory Research

Quality Standards

A documented preparation sequence

Step 1
Quality Review
Step 2
Packaging Verification
Step 3
Batch Documentation
Step 4
Storage Preparation
Step 5
Shipment Processing

Key Research Areas

Laboratory application areas

Common categories where GHRH analog research peptides like Dr. Jays TESA™ support analytical and procedural laboratory work.

GHRH Receptor Signaling

Laboratory investigation of growth hormone-releasing hormone receptor binding and downstream signaling.

Pituitary Function Research

Reference compound for studies on pituitary hormone regulation and feedback systems.

IGF-1 Pathway Investigation

Used in models exploring growth hormone axis activity and IGF-1 pathway dynamics.

Endocrine & Metabolic Models

Applied across endocrine and metabolic research workflows in qualified laboratories.

Peptide-Receptor Studies

Reference material for receptor interaction and binding-affinity investigation.

Cellular Signaling Analysis

Supports downstream signaling pathway evaluation in controlled research environments.

Storage & Handling

Store lyophilized material refrigerated upon receipt.
Follow standard laboratory handling procedures.
Reconstituted materials stored per established research protocols.
Avoid repeated freeze-thaw cycles.

Research Use Only

This product is supplied exclusively for laboratory and scientific research purposes. Not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.

Why Dr. Jay's

Why researchers choose Dr. Jay's

Research Focused

Curated catalog of research peptides for analytical and educational use.

Educational Resources

Knowledge Hub, encyclopedia entries, and structured Peptide University™ modules.

Knowledge Hub Access

Complimentary access to the central educational reference library.

Premium Packaging

Sealed research vials and inspected outer packaging on every order.

Quality Standards

Documented preparation, packaging verification, and batch logging sequence.

Responsive Support

Knowledgeable customer support for order, shipment, and resource inquiries.

Interactive Knowledge Hub

Continue with educational resources

Explore the surrounding library of educational reference material curated by Dr. Jay's.

Peptide Finder™

Navigate the research compound catalog by category, target, and format.

Open resource →

Peptide University™

Structured educational modules covering peptide research fundamentals.

Open resource →

Knowledge Hub

Central educational reference library curated by Dr. Jay's.

Open resource →

Research Guides

In-depth research guides and compound encyclopedia entries.

Open resource →

Reconstitution Reference

How-to-mix reference for lyophilized research peptide reconstitution.

Open resource →

Growth Hormone Secretagogues

Educational guide covering GHRH analogs and growth hormone secretagogue research.

Open resource →

Dr. Jays TESA™ — Frequently asked questions

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95–97% claimed

COA included with every order

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Refund if purity fails

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Cold storage — temperature controlled

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email reply in under 30 minutes

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100% American made & sourced

Synthesized & fulfilled in the USA

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Veteran owned & operated

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Criteria	Dr Jays Peptides	Other peptide vendors
Purity guarantee	98%+ guaranteed	95–97% claimed
COA included with every order		~
Refund if purity fails
Same-Day shipping UPS Cold storage — temperature controlled
Responsive human support email reply in under 30 minutes		~
100% American made & sourced Synthesized & fulfilled in the USA
Veteran owned & operated

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TESA – Research Grade GHRH Analog Peptide

Volume pricing

Dr. Jays TESA™

Engineered for endocrine research workflows

Lyophilized GHRH Analog

5MG & 10MG Vials

BAC Water Included

Educational Resources

What is Dr. Jays TESA™?

GHRH → GH → IGF-1 axis

From compound to documented review

Product specifications

A documented preparation sequence

Laboratory application areas

GHRH Receptor Signaling

Pituitary Function Research

IGF-1 Pathway Investigation

Endocrine & Metabolic Models

Peptide-Receptor Studies

Cellular Signaling Analysis

Storage & Handling

Research Use Only

Why researchers choose Dr. Jay's

Research Focused

Educational Resources

Knowledge Hub Access

Premium Packaging

Quality Standards

Responsive Support

Continue with educational resources

Peptide Finder™

Peptide University™

Knowledge Hub

Research Guides

Reconstitution Reference

Growth Hormone Secretagogues

Dr. Jays TESA™ — Frequently asked questions

What is Dr. Jays TESA™?

What is a GHRH analog peptide?

What does lyophilized mean?

How is Dr. Jays TESA™ supplied?

What strengths are available?

What is the recommended storage condition?

Is bacteriostatic water included?

How is the product packaged for shipment?

What is laboratory-grade handling?

What research resources are available?

How should research compounds be documented?

What are analytical applications?

Is TESA™ intended for human or animal use?

What is GHRH receptor research?

Is the vial tamper-evident?

What if a vial arrives damaged?

How is product quality reviewed?

Where can I find related research compounds?

Is shipping discreet?

What is the typical appearance of the lyophilized powder?

Can the compound be reconstituted?

Is batch documentation available?

What does 'research grade' mean on this page?

How does TESA™ compare to other GHRH research peptides?

Where can I learn more about peptide research fundamentals?

Built on research-product standards

Real reviews from Dr Jays Peptides customers

Why Dr Jays vs. the alternatives

Keep learning about peptides