PE-22-28 vs Selank
TREK-1 antidepressant peptide vs anxiolytic heptapeptide.
| Attribute | PE-22-28 Spadin analog | Selank Tuftsin analog |
|---|---|---|
| Category | Brain & Cognitive Support | Brain & Cognitive Support |
| Best known for | TREK-1 potassium channel antidepressant research | Anxiolytic without sedation research |
| In plain English | It blocks a brain potassium channel involved in mood regulation, aiming for fast-acting antidepressant effects. | Selank is the chill peptide. Researchers study how it provides anti-anxiety effects without the sedation or dependence of benzodiazepines. |
| How it works | Selectively inhibits the TREK-1 two-pore potassium channel, enhancing serotonergic transmission in mood-relevant circuits. | Modulates GABA, serotonin, and BDNF; inhibits enkephalinase to increase enkephalin activity. |
| Researchers study | Depression, anxiety, and stress-resilience models. | Generalized anxiety, stress response, and immune modulation. |
| Internet discussion | Discussed in advanced nootropic and mood research circles. | The anti-anxiety peptide of choice on nootropic forums. |
PE-22-28
TREK-1 potassium channel antidepressant research
It blocks a brain potassium channel involved in mood regulation, aiming for fast-acting antidepressant effects.
Selectively inhibits the TREK-1 two-pore potassium channel, enhancing serotonergic transmission in mood-relevant circuits.
Depression, anxiety, and stress-resilience models.
Discussed in advanced nootropic and mood research circles.
PE-22-28 is a spadin-derived TREK-1 blocker researched as a fast-acting antidepressant peptide.
Selank
Anxiolytic without sedation research
Selank is the chill peptide. Researchers study how it provides anti-anxiety effects without the sedation or dependence of benzodiazepines.
Modulates GABA, serotonin, and BDNF; inhibits enkephalinase to increase enkephalin activity.
Generalized anxiety, stress response, and immune modulation.
The anti-anxiety peptide of choice on nootropic forums.
Selank is an anxiolytic nootropic peptide researched for stress reduction without sedation.