PE-22-28
- •what is PE-22-28
- •PE-22-28 spadin
- •PE-22-28 antidepressant research
- •PE-22-28 TREK-1
- •PE-22-28 depression
- PE-22-28(Spadin analog)· Brain & Cognitive Support
- PE-22-28 is a research peptide that targets one specific brain channel (TREK-1). Blocking it in animal studies produces antidepressant-like effects within hours rather than weeks.
What is it?
PE-22-28 is a synthetic peptide derived from spadin, a natural peptide fragment that selectively blocks the TREK-1 potassium channel. It is studied for rapid-acting antidepressant-like effects in animal research.
In plain English
PE-22-28 is a research peptide that targets one specific brain channel (TREK-1). Blocking it in animal studies produces antidepressant-like effects within hours rather than weeks.
How it works
Selectively inhibits the TREK-1 two-pore-domain potassium channel, which regulates serotonergic neuron excitability and is implicated in mood regulation.
What researchers study
- •Animal models of depression
- •TREK-1 channel pharmacology
- •Rapid-onset antidepressant research
- •Neuroplasticity and serotonin pathway studies
What the internet talks about
Heavily discussed in nootropic and mood-focused communities as a research-stage alternative to SSRIs and ketamine.
Bro-science translation
“The fast-acting research antidepressant peptide.”
Commonly compared to
Common stack discussions
Compared with Semax, Selank, and ketamine in mood research discussions.
Related peptides
Related categories
Frequently asked questions
Quick summary
PE-22-28 is a spadin-derived TREK-1 blocker studied for rapid-acting antidepressant-like effects in animal models.