Mitochondria · Oct 30, 2024
SS-31 (Elamipretide) and Cardiolipin Stabilization
Summary
SS-31 selectively concentrates in the inner mitochondrial membrane and binds cardiolipin, supporting respiratory-chain efficiency.
Why It Matters
Most mitochondrial research compounds act indirectly. SS-31 binds directly inside the organelle — a different mechanism class from MOTS-c and Humanin.
Key Findings
- Cardiolipin-binding documented across multiple research groups.
- Clinical trials in heart-failure-with-preserved-ejection-fraction populations.
- Mitochondrial myopathy and Barth-syndrome research populations also studied.