Peptide Research News
Plain-English summaries of 18 important peptide research stories across six topic areas. Educational only.
Weight Loss
Mar 12, 2025
Retatrutide 48-Week Phase 2: The Largest Weight Loss Readout in Peptide Research
Phase 2 results for retatrutide, Lilly's triple GLP-1/GIP/glucagon agonist, reported mean body-weight reductions of around 24% at 48 weeks at the highest dose.
Nov 2, 2024
SURMOUNT Program Overview: What Tirzepatide Research Has Established
The SURMOUNT family of trials has now reported across obesity, type-2 diabetes, sleep apnea, and heart-failure-with-preserved-ejection-fraction research populations.
Jan 21, 2025
CagriSema: The Amylin + GLP-1 Combination Research Profile
Cagrilintide (an amylin analog) combined with semaglutide is the headline 'next-step' weekly research combination after Wegovy.
Longevity
Sep 18, 2024
What Epitalon Research Actually Shows on Telomerase
Epitalon, the four-amino-acid bioregulator from the pineal-research program in St. Petersburg, has been studied for telomerase activation in cell and rodent models.
Aug 4, 2024
FOXO4-DRI and the Case for Peptide Senolytics
FOXO4-DRI disrupts the FOXO4-p53 interaction that senescent cells use to evade apoptosis, selectively pushing 'zombie cells' to die.
Dec 9, 2024
Why MOTS-c Levels Drop With Age — And What Researchers Are Asking
Circulating MOTS-c levels decline meaningfully after middle age. The peptide is encoded inside mitochondrial DNA and acts as a metabolic regulator.
Brain Health
Oct 15, 2024
Semax and BDNF: The Cognitive Peptide Research Story
Semax, a heptapeptide derived from ACTH, has the longest research record of any modern intranasal cognitive peptide in Russia.
Feb 4, 2025
Dihexa: HGF-Pathway Cognitive Research Peptide
Dihexa is an angiotensin IV analog with high reported potency on the HGF/c-Met pathway, central to synaptogenesis.
Jul 22, 2024
Selank: Anxiolytic Peptide Without Sedation
Selank is a synthetic analog of the immunomodulatory tetrapeptide tuftsin, studied as a non-sedating anxiolytic peptide.
Recovery
Jun 30, 2024
BPC-157 Tendon Research: What the Animal Models Actually Show
BPC-157 has dozens of published animal models covering tendon, ligament, gut, and vascular research. Human data is limited.
May 14, 2024
TB-500: Systemic Tissue Remodeling Research
TB-500 is a synthetic fragment of Thymosin Beta-4 studied for actin binding, angiogenesis, and tissue remodeling.
Apr 9, 2025
KPV: The α-MSH Tripeptide Anti-Inflammatory Story
KPV is a C-terminal tripeptide of α-MSH studied for anti-inflammatory effects without the pigmentation activity of full-length MSH peptides.
Hormones
Sep 2, 2024
Tesamorelin: GHRH Analog With FDA Indication
Tesamorelin is the only FDA-approved GHRH analog, indicated for HIV-associated lipodystrophy, with extensive truncal-fat reduction research.
Dec 19, 2024
Kisspeptin: Upstream of the Entire HPG Axis
Kisspeptin is the upstream regulator of GnRH and the master switch for puberty and reproductive function. Synthetic analogs are an active research area.
Aug 26, 2024
CJC-1295 vs Sermorelin: Why Half-Life Changes Everything
Both are GHRH analogs but sermorelin's half-life is minutes while CJC-1295 with DAC is days. That single difference changes the entire research-use profile.
Mitochondria
Oct 30, 2024
SS-31 (Elamipretide) and Cardiolipin Stabilization
SS-31 selectively concentrates in the inner mitochondrial membrane and binds cardiolipin, supporting respiratory-chain efficiency.
Jun 12, 2024
Humanin: The Survival Peptide Encoded in Mitochondrial DNA
Humanin is a 24-amino-acid peptide encoded in the mitochondrial genome, originally discovered for protecting neurons from amyloid-β toxicity.
Jan 8, 2025
NAD+ and the Mitochondrial Energy Research Discussion
NAD+ is the central coenzyme for the electron-transport chain and the substrate for sirtuins. Its decline with age has driven a wave of restoration research.