Semax vs Dihexa
Russian ACTH analog vs angiotensin-IV–derived synaptogenesis peptide.
| Attribute | Semax ACTH(4-10) analog | Dihexa HGF mimetic peptide |
|---|---|---|
| Category | Brain & Cognitive Support | Brain & Cognitive Support |
| Best known for | Cognitive enhancement research | Synaptogenesis and cognitive restoration research |
| In plain English | Semax is the focus peptide. Researchers study how it boosts BDNF and NGF — the brain's growth and repair factors. | Dihexa is the synapse builder. Researchers study how it physically grows new connections between brain cells. |
| How it works | Upregulates BDNF and NGF expression, modulates dopamine and serotonin, and inhibits enkephalin breakdown. | Activates HGF/c-Met signaling, promoting synaptogenesis and neuronal plasticity. |
| Researchers study | Cognitive function, ischemic stroke recovery, ADHD, and neuroprotection. | Alzheimer's disease, Parkinson's, and cognitive decline. |
| Internet discussion | Stacked with Selank as the canonical Russian nootropic combo. | Heavy hype in nootropic circles. |
Semax
Cognitive enhancement research
Semax is the focus peptide. Researchers study how it boosts BDNF and NGF — the brain's growth and repair factors.
Upregulates BDNF and NGF expression, modulates dopamine and serotonin, and inhibits enkephalin breakdown.
Cognitive function, ischemic stroke recovery, ADHD, and neuroprotection.
Stacked with Selank as the canonical Russian nootropic combo.
Semax is a nootropic peptide researched for BDNF/NGF upregulation and cognitive support.
Dihexa
Synaptogenesis and cognitive restoration research
Dihexa is the synapse builder. Researchers study how it physically grows new connections between brain cells.
Activates HGF/c-Met signaling, promoting synaptogenesis and neuronal plasticity.
Alzheimer's disease, Parkinson's, and cognitive decline.
Heavy hype in nootropic circles.
Dihexa is an HGF-mimicking peptide researched for synaptogenesis and cognitive restoration.