Longevity · Aug 4, 2024
FOXO4-DRI and the Case for Peptide Senolytics
Summary
FOXO4-DRI disrupts the FOXO4-p53 interaction that senescent cells use to evade apoptosis, selectively pushing 'zombie cells' to die.
Why It Matters
Most senolytic research uses small molecules. A peptide senolytic with documented selectivity changes the toolkit for longevity researchers.
Key Findings
- Original Cell paper (Baar et al., 2017) showed restored organ function in aged mice.
- Selectivity for senescent cells appears tied to the FOXO4-p53 interaction.
- No large human clinical readouts to date.