VIP

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide naturally produced in the gut, pancreas, brain, and many other tissues. It belongs to the secretin/glucagon family and was originally discovered for its potent vasodilatory and smooth-muscle-relaxing effects in the gut — hence its name. Decades of research expanded its known roles to include circadian rhythm regulation in the suprachiasmatic nucleus, immune modulation, and anti-inflammatory signaling. Research-grade VIP is sold strictly for laboratory use.

VIP is one of the body's quietly important multitasking peptides. It relaxes smooth muscle, opens blood vessels, helps set the brain's master circadian clock, and calms immune overactivity. In the research peptide world it gets the most attention as a potent anti-inflammatory tool — particularly in sarcoidosis, chronic inflammatory response syndrome (CIRS), and chronic fatigue research circles. Most users encounter it as an intranasal spray.

VIP binds VPAC1 and VPAC2 G-protein-coupled receptors, triggering cAMP signaling. Downstream effects include suppression of pro-inflammatory cytokines (TNF-α, IL-6), upregulation of regulatory T-cells, smooth muscle relaxation, and circadian entrainment via the suprachiasmatic nucleus. The anti-inflammatory profile is broad enough that researchers describe VIP as a 'master regulator' of immune tolerance.

• •Sarcoidosis and chronic inflammatory response syndrome (CIRS)
• •Pulmonary hypertension
• •Circadian rhythm in the suprachiasmatic nucleus
• •Autoimmune disease models
• •Mold biotoxin illness research (Shoemaker protocol)
• •Erectile function and vasodilation

VIP has a devoted following in CIRS and mold-illness communities thanks to Dr. Ritchie Shoemaker's protocols using intranasal VIP as the final 'finish' step. On r/Peptides and chronic-illness forums, threads focus on sourcing reliable intranasal preparations and combining VIP with thymosin alpha-1.

“The body's master inflammation-resetting peptide.”

Often combined with thymosin alpha-1 in immune protocols, with BPC-157 in chronic-pain research, and as the final compound in Shoemaker CIRS protocols. Intranasal dosing is most common.

VIP is a 28-amino-acid multifunctional neuropeptide studied for anti-inflammatory effects, circadian rhythm, and vasodilation. It is central to CIRS and mold-illness research protocols and is sold for laboratory use only.