Palmitoyl Tetrapeptide-20
- •what is Palmitoyl Tetrapeptide-20
- •PTP-20 skin
- •Palmitoyl Tetrapeptide-20 vs Matrixyl
- •lipidated cosmetic peptide
- •anti-aging peptide research
- Palmitoyl Tetrapeptide-20(PTP-20)· Skin, Hair & Beauty
- A skincare peptide engineered to slip through the skin barrier and signal collagen and matrix protein support — a next-generation cousin to Matrixyl.
What is it?
Palmitoyl Tetrapeptide-20 is a synthetic four-amino-acid cosmetic peptide conjugated to a palmitic acid chain for improved skin penetration. It is studied in topical anti-aging formulations.
In plain English
A skincare peptide engineered to slip through the skin barrier and signal collagen and matrix protein support — a next-generation cousin to Matrixyl.
How it works
The palmitoyl tail helps the peptide cross the lipid skin barrier; the peptide portion signals fibroblasts to support extracellular matrix and skin firmness.
What researchers study
- •Cosmetic anti-aging studies
- •Skin barrier penetration research
- •Comparison with Matrixyl and Argireline
- •Fibroblast signaling assays
What the internet talks about
Discussed in DIY skincare and serum formulation communities as a modern alternative to Matrixyl.
Bro-science translation
“A next-gen Matrixyl analog.”
Commonly compared to
Common stack discussions
Combined topically with Matrixyl, GHK-Cu, and Argireline in cosmetic serum stacks.
Related peptides
Related categories
Frequently asked questions
Quick summary
Palmitoyl Tetrapeptide-20 is a lipidated cosmetic peptide studied for skin firmness and barrier signaling.