CJC-1295 DAC

CJC-1295 DAC is the long-acting form of CJC-1295, with an added Drug Affinity Complex (a maleimido-propionic acid linker) that covalently binds serum albumin, extending the half-life from minutes to roughly 6–8 days.

CJC-1295 DAC is the 'set it and forget it' GHRH analog. Instead of producing a sharp pulse, it raises baseline GH and IGF-1 for days at a time — which is exactly why it is loved by some researchers and avoided by others.

Same GHRH receptor binding as standard CJC-1295, but the DAC linker tethers it to circulating albumin, creating a depot that continuously stimulates the pituitary. The result is sustained elevation of GH and IGF-1 rather than discrete pulses.

• •Sustained GH and IGF-1 elevation studies
• •Comparison with pulsatile GHRH analogs
• •Body composition and recovery research
• •Sleep architecture
• •Long-term anti-aging research models

Polarizing in research forums. Fans cite convenience and consistent IGF-1; critics argue that sustained elevation defeats the natural pulsatility that makes GHRH analogs attractive in the first place. Once-weekly dosing is the headline appeal.

“Always-on growth hormone, in one weekly shot.”

Sometimes stacked with Ipamorelin, though many researchers prefer no-DAC CJC + Ipamorelin to preserve pulsatility. Compared head-to-head with Tesamorelin and Sermorelin.

CJC-1295 DAC is the long-acting albumin-bound form of CJC-1295, studied for sustained GH/IGF-1 elevation with once-weekly research dosing.