Kisspeptin vs hCG
| Attribute | Kisspeptin Kisspeptin-10 | hCG Human Chorionic Gonadotropin |
|---|---|---|
| Category | Sexual Function & Hormones | Sexual Function & Hormones |
| Best known for | HPG axis activation research | LH-mimicking fertility research |
| In plain English | Kisspeptin is the 'on switch' for the reproductive hormone cascade. It tells the brain to release the hormone that signals testosterone and estrogen production. | hCG fakes out the testes into thinking the brain is sending an LH signal — keeping them producing testosterone during research protocols. |
| How it works | Stimulates GnRH neurons in the hypothalamus, which then triggers LH and FSH release from the pituitary, leading to gonadal sex hormone production. | Binds the LH receptor on Leydig cells, stimulating testosterone production. |
| Researchers study | Reproductive hormone disorders, puberty timing, fertility, and emotional/sexual brain processing. | Fertility, hypogonadism, and post-cycle hormone restoration. |
| Internet discussion | Discussed as a more 'natural' alternative to hCG for HPG axis support. | Standard PCT discussion topic. |
Kisspeptin
HPG axis activation research
Kisspeptin is the 'on switch' for the reproductive hormone cascade. It tells the brain to release the hormone that signals testosterone and estrogen production.
Stimulates GnRH neurons in the hypothalamus, which then triggers LH and FSH release from the pituitary, leading to gonadal sex hormone production.
Reproductive hormone disorders, puberty timing, fertility, and emotional/sexual brain processing.
Discussed as a more 'natural' alternative to hCG for HPG axis support.
Kisspeptin is a hypothalamic 'master switch' for the reproductive hormone cascade.
hCG
LH-mimicking fertility research
hCG fakes out the testes into thinking the brain is sending an LH signal — keeping them producing testosterone during research protocols.
Binds the LH receptor on Leydig cells, stimulating testosterone production.
Fertility, hypogonadism, and post-cycle hormone restoration.
Standard PCT discussion topic.
hCG mimics LH at the testes and is heavily discussed in fertility and post-cycle protocols.