hCG vs Kisspeptin
| Attribute | hCG Human Chorionic Gonadotropin | Kisspeptin Kisspeptin-10 |
|---|---|---|
| Category | Sexual Function & Hormones | Sexual Function & Hormones |
| Best known for | LH-mimicking fertility research | HPG axis activation research |
| In plain English | hCG fakes out the testes into thinking the brain is sending an LH signal — keeping them producing testosterone during research protocols. | Kisspeptin is the 'on switch' for the reproductive hormone cascade. It tells the brain to release the hormone that signals testosterone and estrogen production. |
| How it works | Binds the LH receptor on Leydig cells, stimulating testosterone production. | Stimulates GnRH neurons in the hypothalamus, which then triggers LH and FSH release from the pituitary, leading to gonadal sex hormone production. |
| Researchers study | Fertility, hypogonadism, and post-cycle hormone restoration. | Reproductive hormone disorders, puberty timing, fertility, and emotional/sexual brain processing. |
| Internet discussion | Standard PCT discussion topic. | Discussed as a more 'natural' alternative to hCG for HPG axis support. |
hCG
LH-mimicking fertility research
hCG fakes out the testes into thinking the brain is sending an LH signal — keeping them producing testosterone during research protocols.
Binds the LH receptor on Leydig cells, stimulating testosterone production.
Fertility, hypogonadism, and post-cycle hormone restoration.
Standard PCT discussion topic.
hCG mimics LH at the testes and is heavily discussed in fertility and post-cycle protocols.
Kisspeptin
HPG axis activation research
Kisspeptin is the 'on switch' for the reproductive hormone cascade. It tells the brain to release the hormone that signals testosterone and estrogen production.
Stimulates GnRH neurons in the hypothalamus, which then triggers LH and FSH release from the pituitary, leading to gonadal sex hormone production.
Reproductive hormone disorders, puberty timing, fertility, and emotional/sexual brain processing.
Discussed as a more 'natural' alternative to hCG for HPG axis support.
Kisspeptin is a hypothalamic 'master switch' for the reproductive hormone cascade.